Asthma and allergic diseases: Cross talk of Immune System and Environmental Factors.

Air pollution and immune-related diseases including allergy and asthma are constantly on the rise world- wide. Thus, a comprehensive investigation of environmentally induced immune regulation is required for a deeper understanding of disease pathogenesis, progression as well as prevention. Here, we summarize the current knowledge on environmental factors such as microbiome or geographical locations with harmful or protective effects for human health and their different routes of exposure. This review comprises a brief outline regarding the latest findings on the interaction of environmental factors with innate and adaptive regulation of the immune system, exemplary for one protective and one harmful environmental factor, respectively. This article is protected by copyright. All rights reserved.