[Study of the safety and immunogenicity of VLP-based vaccine for the prevention of rotavirus infection in neonatal minipig model].

L V Kostina I E Filatov Olesja Eliseeva O E Latyshev Yana Yu Chernoryzh Kirill I Yurlov Ekaterina I Lesnova K M Khametova Stanislav A Cherepushkin T E Savochkina V V Tsibezov Kirill Kryshen L I Alekseeva O N Zaykova Tatiana Vladimirovna Grebennikova

Published in: Voprosy virusologii (2023)

Thus, three-time intramuscular immunization of minipigs with the Gam-VLP-rota vaccine forms stable protective humoral and cellular immunity in experimental animals. Evaluated vaccine is safe and has good local tolerability.

Keyphrases

immune response
open label
double blind