Vascular Adhesion Protein-1 (VAP-1) as Predictor of Radiographic Severity in Symptomatic Knee Osteoarthritis in the New York University Cohort.

Eirini BournazouJonathan SamuelsHua ZhouSvetlana KrasnokutskyJyoti PatelTianzhen HanJenny BencardinoLeon RybakSteven B AbramsonUwe JunkerKaren S BrownMukundan Attur

Published in: International journal of molecular sciences (2019)

Local (synovial fluid) semicarbazide-sensitive amine oxidase (SSAO)/sVAP-1 levels were elevated in OA and correlated with radiographic severity. However, systemic (serum) sVAP-1 levels were lower in SKOA patients than normal and inversely correlated with pain and inflammation markers. Serum sVAP-1 levels were higher in early (KL1/2) compared with advanced (KL3/4) SKOA patients.

Keyphrases

knee osteoarthritis
end stage renal disease
newly diagnosed
chronic kidney disease
oxidative stress
chronic pain
patient reported outcomes
escherichia coli
pseudomonas aeruginosa
patient reported
neuropathic pain