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Heterozygous loss of Srp72 in mice is not associated with major hematological phenotypes.

Teresa D'AltriMikkel B SchusterAnne WenzelBo Torben Porse
Published in: European journal of haematology (2019)
The Srp72+/- mouse model only partially recapitulates the phenotype observed in families with inherited SRP72 lesions. Nonetheless, these results can provide mechanistic insights into why SRP72 mutations are associated with aplasia and myelodysplasia in humans.
Keyphrases
  • mouse model
  • early onset
  • type diabetes
  • high fat diet induced
  • metabolic syndrome
  • adipose tissue
  • insulin resistance