Dynamic nature of BRAF or KRAS p.G12C mutations in second-line therapy for advanced colorectal cancer patients: do early and late effects exist?
Débora Contreras-ToledoPaula Jiménez-FonsecaCarlos López LópezAna Fernández MontesAna María López MuñozFrancisca Vázquez RiveraVicente AlonsoJulia AlcaideFrancesc SalvàMarta Covela RúaMónica GuillotAlfonso Martín CarniceroRaquel Jimeno MateSoledad Cameselle GarcíaElena Asensio MartínezBeatriz González AstorgaAmaya B Fernandez-DiazPaula González VillaroelAnna C Virgili ManriqueMarcos Melián SosaBeatriz AlonsoAntia Cousillas CastiñeirasCarmen Castañón LópezJorge AparicioAlberto Carmona-BayonasPublished in: British journal of cancer (2024)
The dynamic perspective is essential for understanding the behaviour of tumours with specific genotypes, especially from the second line onward. This may be relevant in patient monitoring and treatment decision-making, particularly in cases with distinct mutations.