Cyclic enaminones and a 4-quinazolinone from an unidentified actinomycete of the family Micromonosporaceae.
Desy W TriningsihTao ZhouKeisuke FukayaEnjuro HarunariNaoya OkuDaisuke UrabeYasuhiro IgarashiPublished in: The Journal of antibiotics (2022)
Four novel cyclic enaminones, designated RD4123A-D (1-4), and a new 4-quinazolinone metabolite, RD4123E (5), were isolated from the culture extract of an unidentified actinomycete strain RD004123, which belongs to the family Micromonosporaceae. Structures of 1-5 were determined by spectroscopic analyses using NMR, MS, and electronic circular dichroism (ECD), combined with quantum chemical calculations of ECD and NMR chemical shifts and biosynthetic consideration. Compounds 1-5 showed weak to modest cytotoxicity against murine leukemia P388 cells, while being inactive against bacteria and fungi.
Keyphrases
- high resolution
- magnetic resonance
- molecular dynamics
- induced apoptosis
- solid state
- mass spectrometry
- cell cycle arrest
- oxidative stress
- molecular docking
- density functional theory
- multiple sclerosis
- acute myeloid leukemia
- bone marrow
- ms ms
- monte carlo
- endoplasmic reticulum stress
- signaling pathway
- cell proliferation
- quantum dots