Novel selective PDE type 1 inhibitors cause vasodilatation and lower blood pressure in rats.
Morten LaursenLilliana BeckJan KehlerClaus Tornby ChristoffersenChristoffer BundgaardSusie MogensenTomas Joachim MowEstéfano PinillaJakob Schöllhammer KnudsenElise Røge HedegaardMorten GrunnetUlf SimonsenPublished in: British journal of pharmacology (2017)
These novel PDE1 inhibitors induce vasodilation and lower BP, suggesting a potential use of these vasodilators in the treatment of hypertension and vasospasm.