Preserving the health of the musculoskeletal system is important to maintain a good quality of life, and the bone-muscle crosstalk is crucial in this regard. This latter is largely mediated by extracellular vesicles released by the different cell populations residing in muscle and bone, which deliver cargoes, microRNAs, and proteins being the most relevant ones, to target cells. Extracellular vesicles could be exploited as therapeutic tools, in view of their resistance to destruction in the biological fluid and of the possibility to be functionalized according to the need. Extracellular vesicles are recognized as crucial players in the bone-muscle cross-talk. Additional studies however are required to refine their use as biomarkers of early alterations of the musculoskeletal system, and as potential therapeutic tools.
Keyphrases
- bone mineral density
- skeletal muscle
- healthcare
- public health
- soft tissue
- induced apoptosis
- bone loss
- bone regeneration
- health information
- stem cells
- mesenchymal stem cells
- single cell
- cell therapy
- health promotion
- cell cycle arrest
- cell death
- signaling pathway
- high resolution
- risk assessment
- cell proliferation
- social media
- tandem mass spectrometry
- simultaneous determination