CD147 mediates intrahepatic leukocyte aggregation and determines the extent of liver injury.
Christine YeeNathan M MainAlexandra TerryIgor StevanovskiAnnette MaczurekAlison J MorganSarah CalabroAlison J PotterTina L IemmaDavid G BowenGolo AhlenstielFiona J WarnerGeoffrey W McCaughanSusan V McLennanNicholas A ShackelPublished in: PloS one (2019)
CD147 mediates leukocyte aggregation which is associated with the development of liver injury. This is not a secondary effect, but a cause of injury as aggregate formation proceeds other markers of injury. Leukocyte aggregation has been previously described in inflammation dating back over many decades. Here we demonstrate that leukocyte aggregates determine the extent of liver injury.