Validation of the physiological background correction method for the suppression of the spill-in effect near highly radioactive regions in positron emission tomography.

The spill-in effect is dependent on the activity in the hot region, lesion size and location, as well as post-filtering; and this is more evident in SUVmax than SUVmean. However, the recently proposed background correction method facilitates stability in quantification and enhances the contrast in lesions with low uptake.