A pharmacokinetic model of anti-seizure medication load to guide care in the Epilepsy Monitoring Unit.
Nina J GhosnKevin XieAkash Ranjan PattnaikJames J GuggerColin A EllisElizabeth SweeneyEmily FoxJohn M BernabeiJenaye JohnsonJacqueline BoccanfusoBrian LittErin C ConradPublished in: Epilepsia (2023)
A pharmacokinetic model can accurately estimate ASM levels for patients in the EMU. Lower modeled ASM levels are associated with increased seizure likelihood and seizure severity. We show that ASM load, rather than ASM taper speed, is associated with severe seizures. ASM modeling has the potential to help optimize taper strategy to minimize severe seizures while maximizing diagnostic yield.