The protein kinase Cβ-selective inhibitor, enzastaurin, attenuates amphetamine-stimulated locomotor activity and self-administration behaviors in rats.
Rachel D AltshulerColleen A CarpenterTimothy J FrankeMargaret E GnegyEmily M JutkiewiczPublished in: Psychopharmacology (2019)
These results demonstrate that inhibition of PKCβ will decrease AMPH-stimulated behaviors and neurobiological changes and suggest that PKCβ is potentially a viable target for AMPH use disorder.
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