mGlu3 receptor regulates microglial cell reactivity in neonatal rats.

Manuela ZinniJérôme MairesseJulien PansiotFrancesco FazioLuisa IacovelliNico AntenucciRosamaria OrlandoFerdinando NicolettiDaniel VaimanOlivier Baud

Published in: Journal of neuroinflammation (2021)

Overall, these data show that Grm3 plays a central role in the regulation of microglial reactivity in the immature brain. Selective pharmacological activation of mGlu3 receptors may prevent inflammatory-induced perinatal brain injury.

Keyphrases

brain injury
subarachnoid hemorrhage
cerebral ischemia
inflammatory response
lipopolysaccharide induced
lps induced
neuropathic pain
single cell
high glucose
diabetic rats
oxidative stress
cell therapy
pregnant women
electronic health record
white matter
resting state
drug induced
big data
spinal cord