Nitrosylation of β2-Tubulin Promotes Microtubule Disassembly and Differentiated Cardiomyocyte Beating in Ischemic Mice.
Da Hyeon ChoiSeong Ki KangKyeong Eun LeeJongsun JungEun Ju KimWon-Ho KimYoung-Guen KwonKwang Pyo KimInho JoYoon Jeong ParkSang Ick ParkPublished in: Tissue engineering and regenerative medicine (2023)
This is the first discovery of a new target molecule of NO, β2-tubulin, that can promote normal cardiac beating and cardiomyocyte regeneration. Taken together, we suggest therapeutic potential of Tyr-NO-β2-tubulin, for ischemic cardiomyocyte, which can reduce unexpected side effect of stem cell transplantation, arrhythmogenesis.