Four new tetrahydroanthracene derivatives (1, 3-5) and a known antibiotic, A-39183A (2), were discovered from the marine-sponge-derived actinomycete Streptomyces fumigatiscleroticus HDN10255. Their structures including absolute configurations were elucidated based upon MS and NMR spectroscopic data, ECD calculations, and biogenetic considerations. Compounds 2 and 4 showed considerable cytotoxicity with the best IC50 value of 1.8 μM against HeLa cells.
Keyphrases
- cell cycle arrest
- induced apoptosis
- high resolution
- mass spectrometry
- magnetic resonance
- cell death
- multiple sclerosis
- molecular docking
- ms ms
- electronic health record
- density functional theory
- molecular dynamics
- pi k akt
- molecular dynamics simulations
- endoplasmic reticulum stress
- signaling pathway
- machine learning
- cell proliferation