Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response.

Li DingVijay S MadamsettySpencer KiersOlga AlekhinaAndrey UgolkovJohn DubeJin-San ZhangEnfeng WangShamit K DuttaDaniel M Schmitt Francis J GilesAlan P KozikowskiAndrew P MazarDebabrata MukhopadhyayDaniel D Billadeau

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

These data identify a previously unknown role for GSK-3 kinases in the regulation of the TopBP1/ATR/Chk1 DNA damage response pathway. The data also support the inclusion of patients with PDAC in clinical studies of 9-ING-41 alone and in combination with gemcitabine.

Keyphrases

dna damage response
dna repair
electronic health record
locally advanced
big data
signaling pathway
dna damage
machine learning
protein kinase
data analysis
cell proliferation