C-C chemokine receptor type 7 (CCR7) regulates hepatic CD8 + T cell homeostasis and response to acute liver injury.

Patricia NiemietzMoritz Peiseler Marlene S Kohlhepp Paul Horn Kylie P MatchettYuting WangLeon HaasTianjiao ZhangAlix Bruneau Adrien Guillot Hilmar BergerAnke LiepeltKlaudia WarzechaCatharina DemskeDiana MöckelTwan Lammers Neil Cowan Henderson Felix Heymann Frank Tacke

Published in: Hepatology (Baltimore, Md.) (2024)

Our study demonstrates the involvement of the adaptive immune system in ALF in humans and mice. We identify the CCR7-CCL21 axis as an important regulatory pathway, providing downstream protection against T cell-mediated liver injury.

Keyphrases

liver injury
drug induced
dendritic cells
regulatory t cells
liver failure
transcription factor
high fat diet induced
intensive care unit
binding protein
extracorporeal membrane oxygenation
liver fibrosis