High density and proximity of CD8 + T cells to tumor cells are correlated with better response to nivolumab treatment in metastatic pleural mesothelioma.
Yuting YinRie SakakibaraTakayuki HondaSusumu KirimuraPissacha DaroonpanMasashi KobayashiKohei AndoHideki UjiieTatsuya KatoKichizo KagaTakahiro MitsumuraRyoji NakanoHiroyuki SakashitaShinichi MatsugeHironori IshibashiTakumi AkashiYasuhiro HidaTakao MorohoshiMiyuki AzumaKenichi OkuboYasunari MiyazakiPublished in: Thoracic cancer (2023)
T cells to tumor cells were associated with better response to nivolumab, whereas the proximity of regulatory T cells to tumor cells was associated with worse response, suggesting that the distinct landscape of the TME could be a potential predictor of ICI efficacy in pleural mesothelioma.