The efficacy of low-dose warfarin initiation (3 mg versus 5 mg) in newly diagnosed venous thromboembolism patients among a population with a high prevalence of warfarin-sensitive haplotype of the VKORC1 gene: a randomized controlled trial.

Bundarika SuwanawiboonWannaphorn RotchanapanyaKomkrit MahapromWanna ThongnoppakhunYupaporn LalerdChanin LimwongseNuttawut SermsathanasawadiWeerapat Owattanapanich

Published in: Hematology (Amsterdam, Netherlands) (2022)

The efficacy of a 3 mg warfarin starting dose with subsequent dose adjustment was similar to that of 5 mg on day 8 after warfarin initiation. However, a 5 mg initiating dose resulted in more patients who achieved therapeutic INR on day 5.

Keyphrases

venous thromboembolism
direct oral anticoagulants
newly diagnosed
atrial fibrillation
low dose
end stage renal disease
oral anticoagulants
chronic kidney disease
ejection fraction
peritoneal dialysis
copy number
prognostic factors
patient reported outcomes
genome wide