Blocking CD47 efficiently potentiated therapeutic effects of anti-angiogenic therapy in non-small cell lung cancer.

Xuyao ZhangYichen WangJiajun FanWei ChenJingyun LuanXiaobin MeiShaofei WangYubin LiLi YeSong LiWenzhi TianKai YinDianwen Ju

Published in: Journal for immunotherapy of cancer (2019)

Our research provided evidence that CD47 blockade could sensitize NSCLC to anti-angiogenic therapy and potentiate its anti-tumor effects by enhancing macrophage infiltration and tumor cell destruction, providing novel therapeutics for NSCLC by disrupting CD47/SIRPα interaction and angiogenetic axis.

Keyphrases

small cell lung cancer
nk cells
advanced non small cell lung cancer
cell therapy
adipose tissue
single cell
stem cells
mesenchymal stem cells