Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic juvenile idiopathic arthritis.
Pui Y LeeGrant S SchulertScott W CannaYuelong HuangJacob SundelYing LiKacie J HoytRachel B BlausteinAlexandra WactorThuy DoOlha HalyabarMargaret H ChangFatma DedeogluSiobhan M CaseEsra MeidanMindy S LoRobert P SundelEdward T RichardsonJane W NewburgerMichael S HershfieldMary Beth SonLauren A HendersonPeter A NigrovicPublished in: Annals of the rheumatic diseases (2019)
These findings collectively identify the utility of plasma ADA2 activity as a biomarker of MAS and lend further support to a pivotal role of macrophage activation in this condition.