C1q is increased in cerebrospinal fluid-derived extracellular vesicles in Alzheimer's disease: A multi-cohort proteomics and immuno-assay validation study.

Madhurima ChatterjeeSelcuk ÖzdemirMarcel KunadtMarleen Koel-SimmelinkWalter BoitenLars PiepkornThang V PhamDavide ChiasseriniSander R PiersmaJaco C KnolWiebke MöbiusBrit MollenhauerWiesje M van der FlierConnie R JimenezCharlotte E TeunissenOlaf JahnAnja Schneider

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)

EVs may be utilized as a potential biomarker and may play a so far unprecedented role in immune-regulation in AD.

Keyphrases

cerebrospinal fluid
mass spectrometry
high throughput
cognitive decline
mild cognitive impairment