Dual-Peak Lorentzian CEST MRI for antiretroviral drug brain distribution.
Yutong LiuGabriel C GauthierHoward E GendelmanAditya N BadePublished in: NeuroImmune pharmacology and therapeutics (2022)
We concluded that 3TC levels can be extracted from confounding CEST effects of tissue biomolecules resulting in improved specificity for drug mapping. This algorithm can be expanded to measure a variety of ARVs using CEST MRI.
Keyphrases
- contrast enhanced
- magnetic resonance imaging
- diffusion weighted imaging
- hiv infected
- high resolution
- adverse drug
- human immunodeficiency virus
- white matter
- computed tomography
- resting state
- cerebral ischemia
- magnetic resonance
- brain injury
- antiretroviral therapy
- neural network
- blood brain barrier
- electronic health record
- subarachnoid hemorrhage