BRCA2, ATM, and CDK12 Defects Differentially Shape Prostate Tumor Driver Genomics and Clinical Aggression.

Evan WarnerCameron Herberts Simon FuSteven YipAmanda WongGang WangElie RitchAndrew J Murtha Gillian VandekerkhoveNicolette M FonsecaArkhjamil AngelesArshia BeigiElena SchönlauKevin BejaMatti AnnalaDaniel J KhalafKim N ChiAlexander W Wyatt

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

BRCA2, ATM, and CDK12 defects are each linked to distinct prostate cancer driver genomics and aggression. The consistency of DDR status in longitudinal samples and resolution of allelic status underscores the potential for ctDNA as a diagnostic tool.

Keyphrases

prostate cancer
dna damage
cell cycle
radical prostatectomy
single cell
dna repair
dna damage response
breast cancer risk
single molecule
cell proliferation
oxidative stress
benign prostatic hyperplasia
human health
risk assessment