BRCA2, ATM, and CDK12 Defects Differentially Shape Prostate Tumor Driver Genomics and Clinical Aggression.
Evan WarnerCameron HerbertsSimon FuSteven YipAmanda WongGang WangElie RitchAndrew J MurthaGillian VandekerkhoveNicolette M FonsecaArkhjamil AngelesArshia BeigiElena SchönlauKevin BejaMatti AnnalaDaniel J KhalafKim N ChiAlexander W WyattPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
BRCA2, ATM, and CDK12 defects are each linked to distinct prostate cancer driver genomics and aggression. The consistency of DDR status in longitudinal samples and resolution of allelic status underscores the potential for ctDNA as a diagnostic tool.