Protective effect of pharmacological castration on metabolic perturbations and cardiovascular disease in the hyperglycemic male ApoE-/-:Ins2+/Akita mouse model.
Wilhelmina C M DuivenvoordenMagda NaeimSarah N HopmansSadiya YousefGeoff H WerstuckShawn DasonJehonathan H PinthusPublished in: Prostate cancer and prostatic diseases (2020)
Further characterization of the ApoE-/-:Ins2+/Akita mouse model confirms that pharmacological ADT ameliorated metabolic syndrome and cardiovascular complications. Improved dysglycemia and atherosclerosis associated with increased survival which was longest after degarelix followed by orchiectomy.