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Protective effect of pharmacological castration on metabolic perturbations and cardiovascular disease in the hyperglycemic male ApoE-/-:Ins2+/Akita mouse model.

Wilhelmina C M DuivenvoordenMagda NaeimSarah N HopmansSadiya YousefGeoff H WerstuckShawn DasonJehonathan H Pinthus
Published in: Prostate cancer and prostatic diseases (2020)
Further characterization of the ApoE-/-:Ins2+/Akita mouse model confirms that pharmacological ADT ameliorated metabolic syndrome and cardiovascular complications. Improved dysglycemia and atherosclerosis associated with increased survival which was longest after degarelix followed by orchiectomy.
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