Protective effect of pharmacological castration on metabolic perturbations and cardiovascular disease in the hyperglycemic male ApoE-/-:Ins2+/Akita mouse model.

Wilhelmina C M DuivenvoordenMagda NaeimSarah N HopmansSadiya YousefGeoff H WerstuckShawn DasonJehonathan H Pinthus

Published in: Prostate cancer and prostatic diseases (2020)

Further characterization of the ApoE-/-:Ins2+/Akita mouse model confirms that pharmacological ADT ameliorated metabolic syndrome and cardiovascular complications. Improved dysglycemia and atherosclerosis associated with increased survival which was longest after degarelix followed by orchiectomy.

Keyphrases

mouse model
cardiovascular disease
metabolic syndrome
cognitive decline
high fat diet
cardiovascular risk factors
insulin resistance
type diabetes
mild cognitive impairment
cardiovascular events
free survival
coronary artery disease