Genetic risk of clozapine-induced leukopenia and neutropenia: a genome-wide association study.
Jian-Hua ChenPing YangQian ZhangRuirui ChenPeng WangBenxiu LiuWensheng SunXuemin JianSiying XiangJuan ZhouNingning LiKe WangChengwen GaoYanqin WenChuanhong WuJinmai ZhangYalin ZhaoQiangzhen YangMeihang LiRobert J StewartYuanchao SunDun PanYujuan NiuZhuo WangYi-Feng XuXingwang LiLin HeZhi-Qiang LiYong-Yong ShiPublished in: Translational psychiatry (2021)
The associations provide novel and valuable understanding of the genetic and immune causes of CIL and CIN, which is useful for improving clinical management of clozapine related treatment for schizophrenia. Causal variants and related underlying molecular mechanisms need to be understood in future developments.