Case-only designs for studying the association of antidepressants and hip or femur fracture.
Mark C H de GrootGianmario CandoreMd Jamal UddinPatrick C SouvereinM Sanni AliSvetlana V BelitserConsuelo HuertaRolf H H GroenwoldYolanda AlvarezJim SlatteryJoke KorevaarArno W HoesKit C B RoesAnthonius de BoerIan J DouglasRaymond G SchliengerRobert ReynoldsOlaf H KlungelHelga GardarsdottirPublished in: Pharmacoepidemiology and drug safety (2017)
Case-only designs confirmed the association between AD and HF. The CCO design violated assumptions in this study with regard to exchangeability and length of exposure, and transient effects on outcome. The SCCS seems to be an appropriate design for assessing AD-HF association.