Lysosomotropic beta blockers induce oxidative stress and IL23A production in Langerhans cells.
Gerrit MüllerCharlotte LübowGünther WeindlPublished in: Autophagy (2019)
ATF: activating transcription factor; DC: dendritic cell; ChIP: chromatin immunoprecipitation; gDNA: genomic DNA; IL: interleukin; LAMP1: lysosomal associated membrane protein 1; LC: Langerhans cell; LPS: lipopolysaccharide; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAPK: mitogen-activated protein kinase; MoDC: monocyte-derived DC; MoLC: monocyte-derived Langerhans-like cell; mtDNA: mitochondrial DNA; NAC: N-acetyl-L-cysteine; NLRP3: NLR family pyrin domain containing 3; PBMC: peripheral blood mononuclear cell; PI: propidium iodide; PYCARD/ASC: PYD and CARD domain containing; qRT-PCR: quantitative real-time PCR; ROS: reactive oxygen species; SQSTM1/p62: sequestosome 1; TLR: Toll-like receptor; TRAF6: TNF receptor associated factor 6; TNF: tumor necrosis factor; Ub: ubiquitin.
Keyphrases
- toll like receptor
- dendritic cells
- transcription factor
- peripheral blood
- mitochondrial dna
- inflammatory response
- copy number
- oxidative stress
- single cell
- rheumatoid arthritis
- reactive oxygen species
- immune response
- dna damage
- real time pcr
- nuclear factor
- induced apoptosis
- simultaneous determination
- signaling pathway
- gene expression
- endothelial cells
- cell death
- mass spectrometry
- regulatory t cells
- small molecule
- mesenchymal stem cells
- heat shock
- sensitive detection
- cell cycle arrest
- tandem mass spectrometry
- circulating tumor
- quantum dots
- diabetic rats