Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia.
Masayuki UmedaJing MaBenjamin S BraunKohei HagiwaraTamara WestoverSherif AbdelhamedJuan Martin BarajasMelvin E ThomasMichael P WalshGuangchun SongLiqing TianYanling LiuXiaolong ChenPandurang KolekarQuang TranScott G FoyJamie L MaciaszekAndrew B KleistAmanda R LeontiBengsheng JuJohn EastonHuiyun WuVirginia ValentineMarcus B ValentineYen-Chun LiuRhonda E RiesJenny L SmithEvan ParganasIlaria IacobucciRyan HiltenbrandJonathan MillerJason R MyersEvadnie RampersaudDelaram RahbariniaMichael C RuschGang WuHiroto InabaYi-Cheng WangTodd A AlonzoJames R DowningCharles G MullighanStanley PoundsM Madan BabuJinghui ZhangJeffrey E RubnitzSoheil MeshinchiXiaotu MaJeffery M KlcoPublished in: Blood cancer discovery (2022)
We defined the spectrum of mutations in relapsed pediatric AML and identified UBTF-TDs as a new recurrent genetic alteration. These duplications are more common in children and define a group of AMLs with intermediate-risk cytogenetic abnormalities, FLT3-ITD and WT1 alterations, and are associated with poor outcomes. See related commentary by Hasserjian and Nardi, p. 173. This article is highlighted in the In This Issue feature, p. 171.