The Associations Between Cognitive Prognosis and Kynurenines Are Modified by the Apolipoprotein ε4 Allele Variant in Patients With Dementia.
Arne Olav ErvikStein-Erik Hafstad SolvangJan Erik NordrehaugPer Magne UelandØivind MidttunAudun HildreAdrian McCannOttar NygårdDag AarslandLasse Melvaer GiilPublished in: International journal of tryptophan research : IJTR (2019)
Kynurenic acid, quinolinic acid, picolinic acid, and the kynurenine-to-tryptophan ratio were associated with a significant increase in cognitive decline when the APOEε4 variant was absent, whereas there was a relatively less decline when the APOEε4 variant was present.