Towards a Better Understanding of Endometriosis-Related Infertility: A Review on How Endometriosis Affects Endometrial Receptivity.
Jing ShanDa-Jin LiXiao-Qiu WangPublished in: Biomolecules (2023)
Endometriosis is the most common cause of infertility. Endometrial receptivity has been suggested to contribute to infertility and poor reproductive outcomes in affected women. Even though experimental and clinical data suggest that the endometrium differs in women with endometriosis, the pathogenesis of impaired endometrial receptivity remains incomplete. Therefore, this review summarizes the potential mechanisms that affect endometrial function and contribute to implantation failure. Contemporary data regarding hormone imbalance, inflammation, and immunoregulatory dysfunction will be reviewed here. In addition, genetic, epigenetic, glycosylation, metabolism and microRNA in endometriosis-related infertility/subfertility will be summarized. We provide a brief discussion and perspectives on their future clinical implications in the diagnosis and therapy to improve endometrial function in affected women.
Keyphrases
- polycystic ovary syndrome
- endometrial cancer
- insulin resistance
- oxidative stress
- electronic health record
- big data
- metabolic syndrome
- gene expression
- stem cells
- genome wide
- pregnancy outcomes
- cell therapy
- adipose tissue
- skeletal muscle
- mesenchymal stem cells
- bone marrow
- glycemic control
- deep learning
- smoking cessation
- risk assessment
- machine learning
- cervical cancer screening