PKC-epsilon deficiency alters progenitor cell populations in favor of megakaryopoiesis.

John C KostyakElisabetta LiveraniSatya P Kunapuli

Published in: PloS one (2017)

Enhanced platelet recovery could be due to an increase in megakaryocyte progenitor cells found in PKCε null mice as well as enhanced thrombopoietin-mediated signaling observed in PKCε deficient megakaryocytes. These data suggest that PKCε is a negative regulator of megakaryopoiesis.

Keyphrases

protein kinase
transcription factor
type diabetes
adipose tissue
wild type
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replacement therapy
recombinant human
genetic diversity
artificial intelligence