Club cell protein 16 in sera from trauma patients modulates neutrophil migration and functionality via CXCR1 and CXCR2.

Baolin XuAndrea JanicovaJan Tilmann VollrathPhilipp StörmannLukas MartinIngo MarziSebastian WutzlerFrank HildebrandSabrina EhnertBorna Relja

Published in: Molecular medicine (Cambridge, Mass.) (2019)

CC16 in sera from multiply traumatized patients, notably of those with pneumonia, has significant effects on PMNL. The results suggest an association of CC16 with CXCR1 and CXCR2. Our data suggest that CC16 reduces the migratory capacity of PMNL and thus modulates their function in patients with respiratory complications after trauma.

Keyphrases

trauma patients
cell migration
end stage renal disease
newly diagnosed
chronic kidney disease
ejection fraction
prognostic factors
single cell
peritoneal dialysis
cell therapy
binding protein
small molecule
mesenchymal stem cells
bone marrow
patient reported outcomes
amino acid
deep learning
artificial intelligence