Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses.
Maxime M BosNeil J GouldingMatthew A LeeAmy HofmanMariska BotRené PoolLisanne S VijfhuizenXiang ZhangChihua LiRima MustafaMatt J NevilleRuifang Li-GaoStella TrompetMarian BeekmanNienke R BiermaszDorret I BoomsmaIrene de BoerConstantinos ChristodoulidesAbbas DehghanKo Willems van DijkIan FordMohsen GhanbariBastiaan T HeijmansM Arfan IkramJ Wouter JukemaDennis O Mook-KanamoriFredrik KarpeAnnemarie I LuikL H LumeyArn M J M van den MaagdenbergSimon P MooijaartRenée de MutsertBrenda W J H PenninxPatrick C N RensenRebecca C RichmondFrits R RosendaalNaveed SattarRobert A SchoeversP Eline SlagboomGisela M TerwindtCarisha S ThesingKaitlin H WadeCarolien A WijsmanGonneke WillemsenAeilko H ZwindermanDiana van HeemstRaymond NoordamDeborah A LawlorPublished in: BMC medicine (2021)
Whilst our results suggested that unfavourable sleep traits may not cause widespread metabolic disruption, some notable effects were observed. The evidence for possible effects of insomnia symptoms on glycoprotein acetyls and citrate and longer total sleep duration on creatinine and isoleucine might explain some of the effects, found in MR analyses of these sleep traits on coronary heart disease, which warrant further investigation.