Diverse mutations and structural variations contribute to Notch signaling deregulation in paediatric T-cell lymphoblastic lymphoma.
Julia Salmerón-VillalobosJoan Enric Ramis-ZaldivarOlga BalaguéJaime VerduVerónica CelisConstantino SábadoMarta GarridoSara MatoJavier UrizM José OrtegaAngela Gutierrez-CaminoDaniel SinnettUnai IllarregiMaxime CaronAlexandra RegueiroAna María GaleraBlanca Gonzalez-FarreElias CampoNoelia GarciaDolors ColomerItziar AstigarragaMara AndrésMargarita LlavadorIdoia Martin-GuerreroItziar SalaverriaPublished in: Pediatric blood & cancer (2022)
In summary, the genomic landscape of paediatric T-LBL is similar to that observed in T-ALL, and Notch signaling pathway deregulation remains the cornerstone in its pathogenesis, including not only mutations but fusion genes targeting NOTCH1.