Epigenetic Small-Molecule Screen for Inhibition and Reversal of Acinar Ductal Metaplasia in Mouse Pancreatic Organoids.

Kalina R AtanasovaCorey M PerkinsRanjala RatnayakeJinmai JiangQi-Yin ChenThomas D SchmittgenHendrik Luesch

Published in: bioRxiv : the preprint server for biology (2023)

Our findings demonstrate a unique epigenetic mechanism and suggest that the phenotypic screen developed here may be applied to discover potential treatments for PDAC.

Keyphrases

small molecule
dna methylation
high throughput
gene expression
protein protein
risk assessment