Microtubule disrupting agent-mediated inhibition of cancer cell growth is associated with blockade of autophagic flux and simultaneous induction of apoptosis.

Mohammad HasanainRohit SahaiPraveen PandeyMayank MaheshwariKuldeep ChoyalDeepa GandhiAkhilesh SinghKavita SinghKalyan MitraDipak DattaJayanta Sarkar

Published in: Cell proliferation (2020)

Our data signify that TN-16 is a potent autophagy flux inhibitor and might be suitable for (pre-) clinical use as standard inhibitor of autophagy with anti-cancer activity.

Keyphrases

cell death
endoplasmic reticulum stress
cell cycle arrest
oxidative stress
papillary thyroid
signaling pathway
electronic health record
squamous cell
big data
cell proliferation
lymph node metastasis
squamous cell carcinoma
machine learning
anti inflammatory
data analysis