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miRNA-126-3p carried by human umbilical cord mesenchymal stem cell enhances endothelial function through exosome-mediated mechanisms in vitro and attenuates vein graft neointimal formation in vivo.

Qingxi QuLimei WangWeidong BingYanwen BiChunmei ZhangXuanxuan JingLing-Hong Liu
Published in: Stem cell research & therapy (2020)
These results suggest hucMSC-based miRNA-126-3p gene therapy may be a novel option for the treatment of vein graft disease after CABG.
Keyphrases
  • umbilical cord
  • mesenchymal stem cells
  • gene therapy
  • endothelial cells
  • bone marrow
  • cell therapy
  • coronary artery bypass grafting
  • coronary artery disease
  • atrial fibrillation
  • smoking cessation