S100A4 suppresses cancer stem cell proliferation via interaction with the IKK/NF-κB signaling pathway.

Yong-Tong ZhuYao ZhouXuan ZhouYangchun GuoDaxiong HuangJialin ZhangChunyan WangLongmei Cai

Published in: BMC cancer (2018)

S100A4 is upregulated in MCSCs and possibly enhance the proliferation ability of MCSCs by way of activating the IKK/NF-κB signaling pathway, and S100A4 maybe a hopeful therapeutic target for MCSCs.

Keyphrases

signaling pathway
cancer stem cells
pi k akt
induced apoptosis
epithelial mesenchymal transition
oxidative stress
cell proliferation
nuclear factor