MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy.
Puneeth ShridharMichael S GlennonSoumojit PalChristina J WaldronEthan J ChetkofPayel BasakNicolas G ClavereDipanjan BanerjeeSebastien GingrasJason R BeckerPublished in: Circulation (2023)
Our results show that sarcomere mutations induce cardiomyocyte MDM2 signaling during the earliest stages of disease, and this leads to long-term changes in the myocardial microenvironment.