MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy.

Puneeth ShridharMichael S GlennonSoumojit PalChristina J WaldronEthan J ChetkofPayel BasakNicolas G ClavereDipanjan BanerjeeSebastien GingrasJason R Becker
Published in: Circulation (2023)
Our results show that sarcomere mutations induce cardiomyocyte MDM2 signaling during the earliest stages of disease, and this leads to long-term changes in the myocardial microenvironment.