Sources of systematic error in DCE-MRI estimation of low-level blood-brain barrier leakage.

Cameron ManningMichael StringerBen DickieUna ClancyMaria C Valdés HernandezStewart J WisemanDaniela Jaime GarciaEleni SakkaWalter H BackesMichael IngrischFrancesca M ChappellFergus DoubalCraig BuckleyLaura Michelle ParkesGeoff J M ParkerIan MarshallJoanna M WardlawMichael Jonathan Thrippleton

Published in: Magnetic resonance in medicine (2021)

Measuring subtle BBB leakage with DCE-MRI presents unique challenges and is affected by several confounds that should be considered when acquiring or interpreting such data. The evaluated modifications should improve accuracy in studies of neurodegenerative diseases involving subtle BBB breakdown.

Keyphrases

blood brain barrier
contrast enhanced
magnetic resonance imaging
magnetic resonance
computed tomography
diffusion weighted imaging
cerebral ischemia
drinking water
electronic health record
big data
machine learning
case control
brain injury
artificial intelligence
deep learning
subarachnoid hemorrhage