Cortical atrophy accelerates as cognitive decline worsens in multiple sclerosis.
Anand J C EijlersIris DekkerMenno Michiel SchoonheimKim A MeijerHanneke E HulstPetra J W PouwelsBernard M J UitdehaagFrederik BarkhofHugo VrenkenMenno M SchoonheimJeroen J G GeurtsPublished in: Neurology (2019)
These results indicate that cortical atrophy and cognitive decline accelerate together during the course of MS. Substrates of cognitive decline shifted from worsening lesional pathology in stable RRMS to deep gray matter atrophy in converting RRMS and to accelerated cortical atrophy in PMS only.