A Selective Phosphodiesterase 10A Inhibitor Reduces L-Dopa-Induced Dyskinesias in Parkinsonian Monkeys.

Goichi BeckShunsuke MaeharaPhat Ly ChangStella M Papa

Published in: Movement disorders : official journal of the Movement Disorder Society (2018)

Results show that regulation of striatal cyclic nucleotides by phosphodiesterase 10A inhibition could be a useful therapeutic approach for l-dopa-induced dyskinesia, and therefore data support further studies of selective phosphodiesterase 10A inhibitors for PD therapy. © 2018 International Parkinson and Movement Disorder Society.

Keyphrases

high glucose
diabetic rats
drug induced
electronic health record
oxidative stress
big data
parkinson disease
bone marrow
cell therapy
replacement therapy