DUSP26 induces aortic valve calcification by antagonizing MDM2-mediated ubiquitination of DPP4 in human valvular interstitial cells.
Yongjun WangDong HanTingwen ZhouCheng ChenHong CaoJoe Z ZhangNing MaChun LiuMoshi SongJiawei ShiXin JinFeng CaoNianguo DongPublished in: European heart journal (2021)
DUSP26 promotes aortic valve calcification by inhibiting DPP4 degradation. Our findings identify a previously unrecognized mechanism of DPP4 up-regulation in CAVD, suggesting that DUSP26 silencing or inhibition is a viable therapeutic strategy to impede CAVD progression.
Keyphrases
- aortic valve
- transcatheter aortic valve replacement
- transcatheter aortic valve implantation
- aortic valve replacement
- aortic stenosis
- induced apoptosis
- chronic kidney disease
- endothelial cells
- cell cycle arrest
- signaling pathway
- induced pluripotent stem cells
- oxidative stress
- cell death
- pi k akt
- atrial fibrillation