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Engineering dendritic cell vaccines to improve cancer immunotherapy.

Caleb R PerezMichele De Palma
Published in: Nature communications (2019)
At the interface between the innate and adaptive immune system, dendritic cells (DCs) play key roles in tumour immunity and hold a hitherto unrealized potential for cancer immunotherapy. Here we review the role of distinct DC subsets in the tumour microenvironment, with special emphasis on conventional type 1 DCs. Integrating new knowledge of DC biology and advancements in cell engineering, we provide a blueprint for the rational design of optimized DC vaccines for personalized cancer medicine.
Keyphrases
  • dendritic cells
  • immune response
  • regulatory t cells
  • papillary thyroid
  • healthcare
  • stem cells
  • single cell
  • cell therapy
  • squamous cell
  • peripheral blood
  • mesenchymal stem cells
  • childhood cancer