A specific anti-COVID-19 BNT162b2 vaccine-induced early innate immune signature positively correlates with the humoral protective response in healthy and multiple sclerosis vaccine recipients.
Martina SeveraFabiana RizzoAlessandro SinigagliaDaniela RicciMarilena Paola EtnaGaia ColaFrancesca BovisMaria Chiara BuscarinuCatia ValdarchiGiovanni RistoriSilvia RiccettiChiara PiubelliPierangela PalmeriniAntonio RosatoFederico GobbiStefano BalducciGirolama Alessandra MarfiaMarco SalvettiLuisa BarzonEliana Marina CocciaPublished in: Clinical & translational immunology (2023)
Overall, this study suggests that the vaccine-induced early regulation of innate immunity is mediated by IFN signalling, impacts on the magnitude of adaptive responses and it might be indicative of vaccine-induced humoral protection.