Potential Targets and Mechanisms of Jiedu Quyu Ziyin Decoction for Treating SLE-GIOP: Based on Network Pharmacology and Molecular Docking.

Jie Li Run-Yu Chang Lin-Feng Chen Su-Hai Qian Rong-Yun Wang Ji-le Lan Lin Huang Xing-Hong Ding

Published in: Journal of immunology research (2023)

We investigated the potential targets and signaling pathways of JP against SLE-GIOP in this study. It shows that JP is most likely to achieve the purpose of treating SLE-GIOP by promoting the proliferation and differentiation of osteoblasts. A solid theoretical foundation will be provided for the future study of clinical and experimental topics.

Keyphrases

systemic lupus erythematosus
molecular docking
signaling pathway
disease activity
molecular dynamics simulations
rheumatoid arthritis
high resolution
epithelial mesenchymal transition
network analysis
induced apoptosis
mass spectrometry
endoplasmic reticulum stress
human health