Diagnosis and Outcomes of Late-Onset Wilson's Disease: A National Registry-Based Study.
Christelle NillesMickael Alexandre ObadiaRodolphe SobeskyJérôme DumortierOlivier GuillaudChloé LaurencinCaroline MoreauClaire VanlemmensFabienne Ory-MagneVictor de LedinghenEdouard Bardou-JacquetFrederique FluchèreCorinne ColletNouzha Oussedik-DjebraniFrance WoimantAurélia PoujoisPublished in: Movement disorders : official journal of the Movement Disorder Society (2022)
In the FWDR, late-onset forms of WD affect 8% of patients, mostly with neurological presentations. Thirty percent of the neurological forms were atypical (isolated long-lasting symptoms, inconspicuous brain MRI, no KFR). With personalized treatment, prognosis was good. This study emphasized that WD should be suspected at any age and even in cases of atypical presentation. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Keyphrases
- late onset
- early onset
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- magnetic resonance imaging
- prognostic factors
- cerebral ischemia
- pulmonary embolism
- metabolic syndrome
- magnetic resonance
- computed tomography
- white matter
- type diabetes
- case report
- systematic review
- adipose tissue
- patient reported
- smoking cessation