Optimization and use of near infrared imaging to guide lymph node collection in rhesus macaques (Macaca mulatta).
Jeremy V SmedleyRachele M BochartMiranda FischerHeidi FunderburghVanessa KellyHugh CrankKim ArmantroutOriene ShielMitchell Robertson-LeVayNikki SternbergerBrian SchmalingSheila RobertsVicki SekiguchiMichael ReuszTiah SchwartzKimberly A MeyerGabriela WebbRoxanne M GilbrideNicholas DambrauskasDaniela AndradeMatthew WoodCaralyn LabriolaMichael AxthelmNina DerbyBen Varco-MerthYoshinori FukazawaScott HansenJonah B SachaDonald L SodoraD Noah SatherPublished in: Journal of medical primatology (2022)
These imaging techniques optimize our ability to evaluate immune changes within LNs over time, even in obese macaques. This approach allows for targeted serial biopsies that permit confidence that draining LNs are being harvested throughout the study.