Brain molecular mechanisms in Rasmussen encephalitis.
Dominique Frances LeitnerZiyan LinZacharia SawagedEvgeny KanshinDaniel FriedmanSasha DevoreBeatrix UeberheideJulia W ChangGary W MathernJasper J AninkEleonora AronicaThomas M WisniewskiOrrin DevinskyPublished in: Epilepsia (2022)
In RE, we identified activated immune signaling pathways and immune cell type annotation enrichment that suggest roles of the innate and adaptive immune responses, as well as HLA variants that may increase vulnerability to RE. Follow-up studies could evaluate cell type density and subregional localization associated with top targets, clinical history (neuropathology, disease duration), and whether modulating crosstalk between dendritic and natural killer cells may limit disease progression.